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February 22, 2026Frontiers in MedicineOpen Access

Fulminant amebic colitis complicated by appendiceal perforation and massive abdominal hemorrhage: a case report and literature review

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Authors

XZXin ZhangWLWenxiong LiSZSong Zhao

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Overview

Case report reveals fatal outcomes of Fulminant Amebic Colitis in non-endemic areas, highlighting the need for early identification.

Key Points

  • This report aims to describe a fatal case of fulminant amebic colitis complicated by appendiceal perforation and hemorrhage.
  • Metagenomic next-generation sequencing (mNGS) was utilized for diagnosis.
  • Histopathological confirmation was obtained post-surgery.
  • Surgical interventions included emergent appendectomy and bowel resection.
  • The patient experienced septic shock and recurrent intra-abdominal bleeding post-surgery.
  • Despite treatment, the condition led to a fatal outcome.
  • mNGS effectively identified Entamoeba histolytica infection amid uncertain diagnostics.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/699a9ceb482488d673cd2954https://doi.org/10.3389/fmed.2026.1760895
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Colonic Perforation Secondary to Entamoeba Histolytica Infection: A Case Report2026
  2. 2Massive gastrointestinal bleeding in fulminant amebic colitis: a case report2026
  3. 3Acute Fulminant Amoebic Colitis with Multiple Perforations in a Diabetic Female2025
  4. 4Amoebic Appendicitis: A Rare Parasitic Cause of a Common Surgical Emergency2025
  5. 5Diagnosis of Amoebic Peritonitis in Peritoneal Fluid in a Patient With Acute Intestinal Obstruction: A Case Report2026