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February 22, 2026CureusOpen Access

Decoding Carbapenem Resistance: Detection of Carbapenemase Genes in Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii

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Authors

NMNeha MamgainSwami Rama Himalayan UniversityBKBarnali KakatiSwami Rama Himalayan UniversityVKVijay Kumar

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Implication

Clinical isolates of carbapenem-resistant A. baumannii show high antibiotic resistance, highlighting urgent control needs.

Key Points

  • The study aimed to assess antimicrobial susceptibility and identify carbapenemase genes in carbapenem-resistant A. baumannii isolates.
  • Conducted in a microbiology department and biosciences school.
  • Utilized VITEK-2 automated system for antibiotic susceptibility testing.
  • Employed combined disc test (CDT) for carbapenemase production detection.
  • Performed molecular screening for carbapenemase genes via polymerase chain reaction (PCR).
  • All 100 CRAB isolates were resistant to all tested beta-lactam antibiotics.
  • 97% of isolates showed carbapenemase production using CDT.
  • Molecular analyses confirmed presence of carbapenemase genes: blaOXA-51 (100%), blaNDM-1 (94%), blaOXA-23 (88%), and blaVIM (70%).
  • Notable coexistence of blaNDM-1 and blaOXA-23 (83%), as well as blaNDM-1 and blaVIM (65%).

Cite This Study

Mamgain et al. (2026) studied this question.

synapsesocial.com/papers/699a9d14482488d673cd2c49https://doi.org/10.7759/cureus.103938
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