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February 22, 2026AntibioticsOpen Access

Biofilm Formation in Chicken-Derived Extraintestinal Pathogenic Escherichia coli Alters the Expression of Biofilm- and Virulence-Associated Genes

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Authors

YHYanze HeNKNianling KuangZCZhihui Chang

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Overview

Demonstrates that biofilm formation alters the expression of specific genes in ExPEC, suggesting new infection control strategies.

Key Points

  • This research investigates how biofilm formation affects the expression of biofilm- and virulence-associated genes in chicken-derived ExPEC strains.
  • Optimized biofilm formation conditions for three ExPEC strains using an orthogonal experimental design.
  • Quantified biofilm biomass with crystal violet staining.
  • Compared transcription levels of specific biofilm and virulence genes using Reverse Transcription-quantitative PCR.
  • Nutrient-rich media consistently promoted rapid biofilm formation across strains.
  • Significant upregulation of biofilm-associated genes such as flhC, tolA, qseC, mhpB, and bdcR (p < 0.05).
  • Virulence genes eaeA, LT, fimH, ompF, and iss were significantly upregulated, while Sta levels were reduced (p < 0.05).

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/699a9d50482488d673cd325chttps://doi.org/10.3390/antibiotics15020227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotypic and Genomic Divergence in Biofilm Formation in STEC and Non-STEC Escherichia coli: The Impact of Genomic Plasticity on the Virulence and Persistence of Bovine Isolates2026
  2. 2Associations of Biofilm Capacity with Antimicrobial Resistance and Virulence Genes in Klebsiella pneumoniae from Chickens in Henan, China, 2023–20252026
  3. 3Genetic Relatedness of Multidrug Resistance and Biofilm Production Genes in C. perfringens Isolates from Broilers2025
  4. 4Characterization of Extraintestinal Pathogenic Escherichia coli from Human Clinical and Poultry Samples2025
  5. 5Dynamics of multidrug-resistant avian pathogenic E. coli biofilm formation on various surfaces and its dispersion with phage antibiotic synergism2026 · 1 citations