Key result
An 800 mg sustained-release verapamil overdose causes dysrhythmia and heart block via negative cardiac effects.
Severe verapamil overdose can cause delayed, life-threatening dysrhythmias and heart block requiring aggressive medical therapy and temporary pacemaker placement.
Prompt cardiac monitoring is warranted after verapamil overdose; this case report leaves optimal management open.
Verapamil (VER) is characterized as a calcium channel blocker (CCB) that can be intentionally or unintentionally overdosed. This drug, like other CCBs, inhibits the entry of calcium into vascular and myocardial tissues through L‐type channels. VER exerts negative inotropic and chronotropic effects on the myocardium through antagonistic L‐type calcium channels, and an overdose of this drug can result in a decrease in cardiac output, hypotension, and shock. In this report, we describe a unique case of VER toxicity in a 30‐year‐old woman who experienced a dysrhythmia and heart block after intentionally ingesting 800 mg of sustained‐release VER tablets.
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Malakian et al. (2026) studied this question. An 800 mg overdose of sustained-release verapamil caused dysrhythmia and heart block in a 30-year-old woman due to its negative cardiac effects.
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