Key result
Accidental overdose of 720 mg of verapamil SR resulted in fatal toxicity with a postmortem cardiac blood level of 6000 ng/mL in a patient with preexisting renal and cardiac disease.
Case Report (n=1)
Fatal verapamil toxicity can occur at relatively low overdose amounts (720 mg) in patients with preexisting renal and cardiac disease.
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Supports caution prescribing verapamil in renal/cardiac disease; single case leaves open generalizable toxicity thresholds.
Batalis et al. (2007) conducted a case report in Verapamil toxicity (n=1). Verapamil SR was evaluated on Fatal toxicity and postmortem cardiac blood verapamil level. Accidental overdose of 720 mg of verapamil SR resulted in fatal toxicity with a postmortem cardiac blood level of 6000 ng/mL in a patient with preexisting renal and cardiac disease.
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