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This research assesses the link between pre-treatment testosterone levels and changes in various health outcomes in men on androgen deprivation therapy.

February 22, 2026Andrology

Impact of Pre‐treatment Testosterone Levels on Severity of Adverse Effects in Men on Androgen Deprivation Therapy for Prostate Cancer

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MBM. A. Sequeira BragaHarvard University YGYun GouCentral South University MTMary‐Ellen TaplinDana-Farber Cancer Institute

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Assesses the relationship between pre-treatment testosterone levels and adverse effects in men undergoing androgen deprivation therapy for prostate cancer, highlighting clinical...

Key Points

This research assesses the link between pre-treatment testosterone levels and changes in various health outcomes in men on androgen deprivation therapy.
Evaluated 39 men before and after 24 weeks of androgen deprivation therapy.
Measured body composition using dual-energy x-ray absorptiometry.
Assessed energy and sexual function through designated scales.
Measured total and free testosterone levels using advanced techniques.
Analyzed associations using linear regression.
Total testosterone levels decreased significantly from 471 to 7.7 ng/dL.
Total fat mass increased by 3.7 kg, while lean mass decreased by 2.2 kg.
Participants reported declines in physical function, energy, and sexual desire.
No association was found between pre-treatment testosterone levels and the degree of worsening in health outcomes.

Cite This Study

Braga et al. (2026) studied this question.

synapsesocial.com/papers/699a9d7a482488d673cd35b2 https://doi.org/10.1111/andr.70194

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Implication

Assesses the relationship between pre-treatment testosterone levels and adverse effects in men undergoing androgen deprivation therapy for prostate cancer, highlighting clinical...

Impact of Pre‐treatment Testosterone Levels on Severity of Adverse Effects in Men on Androgen Deprivation Therapy for Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of Pre‐treatment Testosterone Levels on Severity of Adverse Effects in Men on Androgen Deprivation Therapy for Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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