What does this research mean for the field?

Malnutrition in adults is associated with significant alterations in the hypothalamic–pituitary axis, characterized by low levels of sT3, LH, and IGF-1, while TSH remains normal. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to interpret how malnutrition affects the endocrine system's hormone levels in adults.

February 22, 2026

Hormonal Adaptations of the Pituitary Axis in Malnourished Adults: Clinical Associations

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Authors

KKKamil KonurRecep Tayyip Erdoğan University SASare Şeyma AkustaState Hospital GAGülfidan AtanRecep Tayyip Erdoğan University

Discussion

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Implication

Single-center analysis reveals malnutrition alters endocrine pathways, indicating need for nutritional intervention.

Key Points

This research aims to interpret how malnutrition affects the endocrine system's hormone levels in adults.
Retrospective analysis of medical records of 71 adults diagnosed with malnutrition according to GLIM criteria.
Assessment of anthropometric parameters, biochemical markers, and pituitary hormones based on laboratory reference ranges.
Statistical analyses included Shapiro–Wilk test for normality and multivariable logistic regression.
90% of patients had low sT3 levels, and 38% exhibited low sT4 levels while TSH remained normal in 70%.
92% of patients had reduced IGF-1 levels, with GH levels remaining within normal ranges.
A one standard deviation increase in albumin decreased the likelihood of low sT3 and LH, while increased CRP levels correlated with low IGF-1.

Cite This Study

Konur et al. (2025) studied this question.

synapsesocial.com/papers/699a9de0482488d673cd4101 https://doi.org/10.31832/smj.1796715

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February 22, 2026

Hormonal Adaptations of the Pituitary Axis in Malnourished Adults: Clinical Associations

View Full Paper

Ask AI

Bookmark

Authors

KKKamil KonurRecep Tayyip Erdoğan University SASare Şeyma AkustaState Hospital GAGülfidan AtanRecep Tayyip Erdoğan University

Discussion

Member takes

Implication

Single-center analysis reveals malnutrition alters endocrine pathways, indicating need for nutritional intervention.

Key Points

This research aims to interpret how malnutrition affects the endocrine system's hormone levels in adults.
Retrospective analysis of medical records of 71 adults diagnosed with malnutrition according to GLIM criteria.
Assessment of anthropometric parameters, biochemical markers, and pituitary hormones based on laboratory reference ranges.
Statistical analyses included Shapiro–Wilk test for normality and multivariable logistic regression.
90% of patients had low sT3 levels, and 38% exhibited low sT4 levels while TSH remained normal in 70%.
92% of patients had reduced IGF-1 levels, with GH levels remaining within normal ranges.
A one standard deviation increase in albumin decreased the likelihood of low sT3 and LH, while increased CRP levels correlated with low IGF-1.

Cite This Study

Konur et al. (2025) studied this question.

synapsesocial.com/papers/699a9de0482488d673cd4101 https://doi.org/10.31832/smj.1796715

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