What question did this study set out to answer?

Determine whether malnutrition independently alters immune profiles and neutrophil function in otherwise healthy individuals without active infection.

August 22, 2016PLoS ONEOpen Access

Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function

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Authors

YTYegnasew Takele EAEmebet Adem MGMuluwork Getahun

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Overview

Observational study reveals heightened mixed cytokines and impaired neutrophil function in malnourished healthy individuals, suggesting pre-existing immune vulnerability to infections.

Key Points

Determine whether malnutrition independently alters immune profiles and neutrophil function in otherwise healthy individuals without active infection.
Stratified infection-free participants into three groups by body mass index: normal weight (BMI ≥ 18.5), moderately malnourished (BMI 16.5–18.4), and severely malnourished (BMI < 16.5).
Measured hematological parameters, CD4+ and CD8+ T-cell subsets, plasma cytokines, arginase activity, CD3ζ expression, and neutrophil functions including phagocytosis and reactive oxygen species generation.
Lower BMI correlated significantly with elevated concentrations of Th1 cytokines (IFN-γ, IL-2, IL-12), Th2 cytokines (IL-4, IL-5, IL-13), IL-10, IL-33, and TNF-α, without differences in IL-8, CRP, or CD4+/CD8+ ratios.
Neutrophils retained phagocytic capacity but showed impaired reactive oxygen species production and an increased frequency of low-density neutrophils, most prominently in the severely malnourished group.

Cite This Study

Takele et al. (2016) studied this question.

synapsesocial.com/papers/6a72d123c8eae15310087178 https://doi.org/10.1371/journal.pone.0157919

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August 22, 2016PLoS ONEOpen Access

Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function

View Full Paper

Ask AI

Bookmark

Authors

YTYegnasew Takele EAEmebet Adem MGMuluwork Getahun

Discussion

Member takes

Overview

Observational study reveals heightened mixed cytokines and impaired neutrophil function in malnourished healthy individuals, suggesting pre-existing immune vulnerability to infections.

Key Points

Determine whether malnutrition independently alters immune profiles and neutrophil function in otherwise healthy individuals without active infection.
Stratified infection-free participants into three groups by body mass index: normal weight (BMI ≥ 18.5), moderately malnourished (BMI 16.5–18.4), and severely malnourished (BMI < 16.5).
Measured hematological parameters, CD4+ and CD8+ T-cell subsets, plasma cytokines, arginase activity, CD3ζ expression, and neutrophil functions including phagocytosis and reactive oxygen species generation.
Lower BMI correlated significantly with elevated concentrations of Th1 cytokines (IFN-γ, IL-2, IL-12), Th2 cytokines (IL-4, IL-5, IL-13), IL-10, IL-33, and TNF-α, without differences in IL-8, CRP, or CD4+/CD8+ ratios.
Neutrophils retained phagocytic capacity but showed impaired reactive oxygen species production and an increased frequency of low-density neutrophils, most prominently in the severely malnourished group.

Cite This Study

Takele et al. (2016) studied this question.

synapsesocial.com/papers/6a72d123c8eae15310087178 https://doi.org/10.1371/journal.pone.0157919

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