What question did this study set out to answer?

The study aims to evaluate the effect of comprehensive genome profiling on treatment decisions in patients with metastatic or recurrent breast cancer.

February 22, 2026Clinical Cancer Research

Abstract PS2-08-27: Final Analysis of a Prospective Observational Study to Evaluate the Impact of Comprehensive Genome Profiling on Treatment Decision Making in Metastatic or Recurrent Breast Cancer in Japan: JBCRG-C07 REIWA Study

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The study aims to evaluate the effect of comprehensive genome profiling on treatment decisions in patients with metastatic or recurrent breast cancer.
Prospective observational design focusing on stage IV or recurrent MBC patients.
Enrolled 576 patients consented to FoundationOne testing (CDx and Liquid CDx).
Determined the rate of receiving matched therapy (MT) and its clinical utility, including overall survival.
62.8% of patients recommended for MT actually received it.
Overall survival was significantly longer in the MT group (21.1 months) versus non-MT (14.4 months), with HR 0.651.
OS improvement mainly observed in the luminal subtype (22.3 months) compared to non-significant differences in other subtypes.

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Implication

Prospective observational study evaluates matched therapy impact on outcomes in metastatic breast cancer, suggesting improved survival with tailored treatment.

Cite This Study

Tada et al. (2026) studied this question.

synapsesocial.com/papers/699a9e0e482488d673cd47fb https://doi.org/10.1158/1557-3265.sabcs25-ps2-08-27

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Implication

Prospective observational study evaluates matched therapy impact on outcomes in metastatic breast cancer, suggesting improved survival with tailored treatment.

Abstract PS2-08-27: Final Analysis of a Prospective Observational Study to Evaluate the Impact of Comprehensive Genome Profiling on Treatment Decision Making in Metastatic or Recurrent Breast Cancer in Japan: JBCRG-C07 REIWA Study

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Discussion

Implication

Cite This Study

Abstract PS2-08-27: Final Analysis of a Prospective Observational Study to Evaluate the Impact of Comprehensive Genome Profiling on Treatment Decision Making in Metastatic or Recurrent Breast Cancer in Japan: JBCRG-C07 REIWA Study

Key Points

Discussion

Implication

Cite This Study

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