What question did this study set out to answer?

To identify genomic and immunologic biomarkers associated with pathologic complete response following neoadjuvant chemotherapy in early breast cancer patients.

February 19, 2026Clinical Cancer Research

Abstract PS5-07-07: Toward optimization of treatment strategies for early breast cancer: a multicenter observational study integrating whole genome and transcriptome sequencing within the National Whole Genome Project in Japan (WJOG16822B)

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Authors

JMJun MasudaThe Cancer Institute Hospital YOY. OzakiJapanese Foundation For Cancer Research MKM. KuboKyushu University

Discussion

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Implication

Multicenter observational study identifies biomarkers for treatment response in early breast cancer, suggesting new strategies.

Key Points

To identify genomic and immunologic biomarkers associated with pathologic complete response following neoadjuvant chemotherapy in early breast cancer patients.
Conducted a multicenter, prospective observational cohort study at 17 sites.
Collected tumor samples and blood samples before chemotherapy and surgery.
Performed whole genome sequencing (WGS) and RNA sequencing on tumor and blood samples.
Evaluated immune cell infiltration using multiplex immunohistochemistry.
Analyzed circulating tumor DNA for genomic profiling and minimal residual disease.
Identified specific genomic and immunologic biomarkers associated with pathologic complete response (pCR).
Found significant associations between biomarkers and survival outcomes, including invasive disease-free survival and overall survival.
Established a framework for clinical reporting of WGS results to participants.

Cite This Study

Masuda et al. (2026) studied this question.

synapsesocial.com/papers/6996a8e3ecb39a600b3f016a https://doi.org/10.1158/1557-3265.sabcs25-ps5-07-07

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Abstract PS5-07-07: Toward optimization of treatment strategies for early breast cancer: a multicenter observational study integrating whole genome and transcriptome sequencing within the National Whole Genome Project in Japan (WJOG16822B)

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PS5-07-07: Toward optimization of treatment strategies for early breast cancer: a multicenter observational study integrating whole genome and transcriptome sequencing within the National Whole Genome Project in Japan (WJOG16822B)

Discussion

Member takes

Implication

Key Points

Cite This Study

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