High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
Why the study?
Does atorvastatin 80 mg per day reduce the overall incidence of strokes and cardiovascular events in patients with recent stroke or TIA and without known coronary heart disease?
Population
Patients with recent stroke or TIA and without known coronary heart disease
Design
RCT
Authors
Discussion
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Member takes
Implication
Supports high-dose atorvastatin after recent stroke or TIA without CHD; extends statin benefit to secondary stroke prevention.
Key Points
- To determine whether daily high-dose atorvastatin reduces the risk of recurrent strokes and cardiovascular events in patients with a recent stroke or transient ischemic attack who do not have known coronary heart disease.
- Randomized clinical trial (ClinicalTrials.gov: NCT00147602) evaluating daily atorvastatin at a dose of 80 mg.
- Enrolled patients with a recent stroke or transient ischemic attack (TIA) and no known coronary heart disease.
- Atorvastatin (80 mg daily) reduced the overall incidence of recurrent strokes and major cardiovascular events.
- A small increase in the incidence of hemorrhagic stroke was observed in the atorvastatin group.
Structured PICO
Does atorvastatin 80 mg per day reduce the overall incidence of strokes and cardiovascular events in patients with recent stroke or TIA and without known coronary heart disease?
P
Population
Patients with recent stroke or TIA and without known coronary heart disease
I
Intervention
Atorvastatin 80 mg per day
O
Outcome
Overall incidence of strokes and of cardiovascular eventshard clinical
High-dose atorvastatin (80 mg/day) reduces the incidence of strokes and cardiovascular events in patients with recent stroke or TIA without known coronary heart disease, though it carries a small risk of increased hemorrhagic stroke.
Cite This Study
Pierre Amarenco (2006) studied this question.