Why the study?
Does atorvastatin 80 mg/day increase the risk of hemorrhagic stroke in patients with recent stroke or TIA?
Population
4,731 patients with recent stroke or TIA
Comparison
Atorvastatin 80 mg/day vs Placebo
Design
Cohort
Authors
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May warrant caution with high-dose atorvastatin after recent stroke or TIA, especially prior hemorrhage; leaves open causality and need for confirmation.
Does atorvastatin 80 mg/day increase the risk of hemorrhagic stroke in patients with recent stroke or TIA?
In patients with recent stroke or TIA, atorvastatin 80 mg/day increases the risk of hemorrhagic stroke, particularly in those with prior hemorrhagic stroke, older age, male sex, or uncontrolled hypertension, independent of LDL levels.
Vergouwen et al. (2009) studied this question.
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