What does this research mean for the field?

Submucosal administration of methylprednisolone effectively reduces postoperative pain, swelling, and trismus following impacted mandibular third molar extraction, comparable to intramuscular administration. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate and compare the efficacy of submucosal versus intramuscular methylprednisolone in managing postoperative outcomes after third molar surgery.

February 24, 2026Advances in Oral and Maxillofacial SurgeryOpen Access

“ Evaluation and Comparison of Locally Infiltrated Methylprednisolone and Intramuscularly Injected Methylprednisolone in controlling the postoperative sequelae of impacted mandibular third molar extraction”.

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Authors

JAJunaid AshrafLovely Professional University SDSubhas Chandra DebnathUniversity of Kalyani BDBhagyashree DekaTezpur University

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Implication

Prospective observational study compares submucosal and intramuscular methylprednisolone in reducing postoperative pain and swelling in patients after tooth extraction, suggesting effective...

Key Points

To evaluate and compare the efficacy of submucosal versus intramuscular methylprednisolone in managing postoperative outcomes after third molar surgery.
Conducted a prospective observational clinical study with 105 patients.
Divided patients into three groups: submucosal methylprednisolone, intramuscular methylprednisolone, and control.
Assessed postoperative pain, swelling, trismus, and analgesic use on days 2 and 7.
Both methylprednisolone groups had significantly reduced pain, swelling, trismus, and analgesic use compared to controls (p < 0.05).
No significant difference was observed between the two administration routes.
A single preoperative dose of methylprednisolone effectively lowered postoperative morbidity.

Cite This Study

Ashraf et al. (2026) studied this question.

synapsesocial.com/papers/699d3f9ede8e28729cf643e0 https://doi.org/10.1016/j.adoms.2026.100648

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Implication

Prospective observational study compares submucosal and intramuscular methylprednisolone in reducing postoperative pain and swelling in patients after tooth extraction, suggesting effective...

“ Evaluation and Comparison of Locally Infiltrated Methylprednisolone and Intramuscularly Injected Methylprednisolone in controlling the postoperative sequelae of impacted mandibular third molar extraction”.

Discussion

Member takes

Implication

Key Points

Cite This Study

“ Evaluation and Comparison of Locally Infiltrated Methylprednisolone and Intramuscularly Injected Methylprednisolone in controlling the postoperative sequelae of impacted mandibular third molar extraction”.

Discussion

Member takes

Implication

Key Points

Cite This Study

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