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This study investigates the efficacy of WellPet™, a fluralaner-based ectoparasiticide, against S. scabiei and O. cynotis in naturally infested dogs.

February 24, 2026Parasites & VectorsOpen Access

Efficacy of a fluralaner-based ectoparasiticide for the control of otodectic and sarcoptic mange in naturally infested dogs, evaluated in randomized, double-blind clinical studies

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Randomized clinical studies evaluate the acaricidal efficacy of fluralaner in managing mange in dogs, suggesting effective treatment options.

This study investigates the efficacy of WellPet™, a fluralaner-based ectoparasiticide, against S. scabiei and O. cynotis in naturally infested dogs.
Conducted two randomized, double-blind clinical studies with 14 dogs each.
Divided animals into Control (treated with sarolaner) and treated groups (with fluralaner).
Acaricidal efficacy assessed through mite counts and lesion evaluations.
Significant reduction in S. scabiei mite counts by WellPet™ with 100% efficacy by day 28 (p = 0.022).
Control group required retreatment for 100% efficacy by day 44.
WellPet™ showed 94.1% efficacy against O. cynotis by day 14, reaching 100% by day 21.

Cruz et al. (2026) studied this question.

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Randomized clinical studies evaluate the acaricidal efficacy of fluralaner in managing mange in dogs, suggesting effective treatment options.