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February 24, 2026Gut PathogensOpen Access

Metagenomic analysis of the human gut virome reveals functional signatures and viral stability across hospitalized and non-hospitalized diarrheal and non-diarrheal individuals

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Authors

ARAlejandro RamirezLPLuisa PáezLVLaura Vega

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Overview

Metagenomic analysis reveals functional shifts in the gut virome of hospitalized and non-hospitalized individuals, highlighting viral resilience.

Key Points

  • This research aims to explore the taxonomic composition and functional potential of the gut virome in various clinical conditions, specifically in Latin American populations.
  • Hybrid metagenomic analysis of 37 fecal samples from different groups
  • Taxonomic and functional profiling of viruses
  • Detection of viral auxiliary metabolic genes (vAMGs)
  • Identified 494 high-quality viral operational taxonomic units (vOTUs)
  • Non-diarrheic individuals had a higher diversity of vAMGs compared to hospitalized groups
  • Modest shifts in functional composition linked to diarrhea status rather than hospitalization

Cite This Study

Ramirez et al. (2026) studied this question.

synapsesocial.com/papers/699d3fe6de8e28729cf64ba5https://doi.org/10.1186/s13099-026-00811-x
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