What question did this study set out to answer?

This study aims to assess the bioavailability and efficacy of xanthohumol in humans through different formulations and dosages.

The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data

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Randomized controlled trial shows dose-dependent bioavailability of xanthohumol, suggesting formulation impacts efficacy.

This study aims to assess the bioavailability and efficacy of xanthohumol in humans through different formulations and dosages.
Conducted a randomized crossover trial
Administered 86 mg and 172 mg doses of micellar and native xanthohumol
Collected blood samples at fasting and at intervals up to 24 hours
Analyzed plasma concentrations of xanthohumol and its metabolites
Micellar formulation increased plasma concentration and area under the curve significantly
Bioavailability was approximately 9-fold higher for micellar xanthohumol compared to the native form
Dose-dependent increase observed in maximum plasma concentrations for both formulations
No acute effects on energy expenditure, blood pressure, or heart rate from micellar xanthohumol

Brehmer‐Henkel et al. (2026) studied this question.

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