Why the study?
Does elevated antemortem visit-to-visit blood pressure variability predict postmortem cerebrovascular lesion burden in patients with autopsy-confirmed Alzheimer's Disease?
Does elevated antemortem visit-to-visit blood pressure variability predict postmortem cerebrovascular lesion burden in patients with autopsy-confirmed Alzheimer's Disease?
Antemortem blood pressure variability is associated with increased atherosclerotic and arteriolosclerotic brain lesions in Alzheimer's disease, suggesting a potential mechanism for cognitive decline independent of average blood pressure.
Should not yet alter BP management in AD; leaves open whether targeting variability reduces cerebrovascular lesions.
Findings suggest that elevated blood pressure variability is related to postmortem cerebrovascular lesion burden in autopsy-confirmed AD, independent of average blood pressure and AD neuropathology. Blood pressure fluctuation may selectively promote atherosclerotic and arteriolosclerotic brain lesions with potential implications for cognitive impairment and dementia.
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Sible et al. (2021) studied this question.
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