Key result
Review assesses whether elevated BP variability independently predicts future Alzheimer disease biomarkers and neurodegeneration.
Why the study?
It remains unclear whether high blood pressure variability independently predicts AD-specific pathophysiology and neurodegeneration within the amyloid/tau/neurodegeneration framework, beyond its association with stroke and cerebral small vessel disease.
Does elevated blood pressure variability predict future Alzheimer disease biomarker abnormalities?
Does elevated blood pressure variability predict future Alzheimer disease biomarker abnormalities?
This narrative review highlights the potential role of blood pressure variability as an independent predictor of Alzheimer disease-specific biomarker abnormalities, suggesting a link between vascular risk factors and neurodegeneration.
High BPV signals dementia risk beyond hypertension; leaves open independent AD-specific neurodegeneration.
Increased blood pressure variability (BPV) is associated with increased risk for dementia, independent of hypertension. The increased risk for dementia associated with high BPV includes probable Alzheimer disease (AD) dementia, but high BPV is also associated with increased risk of stroke and cerebral small vessel disease, which are commonly comorbid with AD. This raises the question of whether high BPV is independently predictive of AD-specific pathophysiology and neurodegeneration, which could have significant clinical implications. Fewer studies have directly addressed this question by examining whether higher BPV predicts future AD biomarker abnormalities that are specific to AD pathophysiology within the amyloid/tau/neurodegeneration framework. This narrative review summarizes current studies on this topic and discusses future directions in the investigation of elevated BPV as a risk factor for AD, the most common cause of dementia in older adults.
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Lohman et al. (2026) conducted a review in Alzheimer disease and dementia. Blood pressure variability was evaluated on Alzheimer disease biomarker abnormalities. This narrative review summarizes current evidence on whether elevated blood pressure variability independently predicts future Alzheimer disease biomarker abnormalities and neurodegeneration.
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