Why the study?
Blood pressure variability has shown predictive value over blood pressure levels alone in stroke patients, but whether it predicts cognitive and functional decline in Alzheimer disease was unknown.
Does higher blood pressure variability predict cognitive and functional decline in patients with mild-to-moderate Alzheimer disease?
Does higher blood pressure variability predict cognitive and functional decline in patients with mild-to-moderate Alzheimer disease?
Higher visit-to-visit and day-to-day blood pressure variability is associated with faster cognitive decline in patients with mild-to-moderate Alzheimer disease.
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Higher systolic BPV may flag faster cognitive decline in mild-moderate AD; hypothesis-generating, prospective trials needed.
Heus et al. (2019) studied this question.
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