Key result
This review highlights the clinical evidence and underlying mechanisms linking visit-to-visit blood pressure variability to Alzheimer's disease pathogenesis.
Why the study?
Is visit-to-visit blood pressure variability associated with Alzheimer's disease?
Is visit-to-visit blood pressure variability associated with Alzheimer's disease?
This review highlights the potential role of visit-to-visit blood pressure variability as a modifiable risk factor and therapeutic target for Alzheimer's disease.
Hypothesis-generating link between BP variability and Alzheimer's; prospective trials needed before any practice change.
Alzheimer's disease is the most common type of dementia and one of the leading sources of disability and dependency in the elderly. Given the limited treatment options, understanding the role of modifiable risk factors implied in the disease pathogenesis is a worthwhile endeavor to limit its global burden. Recently, the variability of blood pressure has been suggested to be a significant determinant of brain alterations and a potential therapeutic target. The aim of this article is to review the clinical evidence on the association between visit-to-visit blood pressure variability and Alzheimer's disease, highlight the underlying mechanisms, and suggest future implications.
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Lattanzi et al. (2018) conducted a review in Alzheimer's disease. Visit-to-visit blood pressure variability was evaluated. This review highlights the clinical evidence and underlying mechanisms linking visit-to-visit blood pressure variability to Alzheimer's disease pathogenesis.
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