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The aim is to explore the spatiotemporal dynamics of wing development in silkworms and the role of hormone signaling.

February 25, 2026Nature CommunicationsOpen Access

Single-cell and spatial transcriptomics define 20E-driven developmental reprogramming in silkworm wing disc

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The aim is to explore the spatiotemporal dynamics of wing development in silkworms and the role of hormone signaling.
Constructed a spatiotemporal single-cell atlas of silkworm wing discs across 10 timepoints.
Identified 12 major cell types and their developmental transitions.
Conducted time-resolved single-nucleus RNA sequencing to reveal transcriptional reprogramming.
Analyzed the effects of 20-hydroxyecdysone treatment on gene expression and fate transitions.
Mapped hierarchical transcriptional changes with wing morphogenesis cells as early signaling hubs.
Demonstrated that 20-hydroxyecdysone accelerates fate transitions and gene expression within hours.
Proposed a five-stage Gene Transition Model for wing development.

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Single-cell analysis identifies fate transitions in silkworm wings, suggesting potential for insect development manipulation.

Liu et al. (2026) studied this question.

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