Key result
Higher non-HDL to HDL ratio linked to ~34% increased risk of cholelithiasis.
Why the study?
Does an elevated ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) increase the risk of incident cholelithiasis in health examination participants?
Population
65,362 participants from a tertiary hospital in northeastern China who underwent at least two health…
Comparison
Highest quartile of the ratio of… vs Lowest quartile (Q1) of NHHR
Design
Cohort
Authors
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Elevated NHHR is significantly associated with an increased risk of incident cholelithiasis, demonstrating a U-shaped relationship with a nadir at approximately 1.84.
Cohort (n=65,362)
No
Does an elevated ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) increase the risk of incident cholelithiasis in health examination participants?
Hazard Ratio: 1.34 (95% CI 1.12–1.61)
p-value: p=< 0.001
Elevated NHHR is significantly associated with an increased risk of incident cholelithiasis, demonstrating a U-shaped relationship with a nadir at approximately 1.84.
Ming et al. (2025) conducted a cohort in cholelithiasis (n=65,362). Ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) vs. Lowest NHHR quartile (Q1) was evaluated on incidence of cholelithiasis (HR 1.34, 95% CI 1.12-1.61, p=< 0.001). Participants in the highest quartile of the non-HDL to HDL cholesterol ratio had an increased risk of developing cholelithiasis compared to the lowest quartile (HR 1.34; 95% CI 1.12-1.61; P<0.001).
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