Divergent Transformations of N-Phenyl-N-tosylfluoroacetamides to Amides and Imides (N-Tosylamides)

Nan Wang; Xia Chen; Chun-Yan Liu; Zhi-Ying Feng; Ming Bao; Xiaoyu Zhou

doi:10.1039/d6qo00069j

January 1, 2026Organic Chemistry Frontiers

Divergent Transformations of N-Phenyl-N-tosylfluoroacetamides to Amides and Imides (N-Tosylamides)

View Full Paper

Ask AI

Bookmark

Share

Key Points

The research aims to explore the transformations of N-phenyl-N-tosylfluoroacetamides into amides and imides.
Utilized transition-metal-free nucleophilic addition pathways
Employed various nucleophilic reagents such as indoles, indolines, aryl amines, and carboxylic acids
Analyzed the activation of the C−N bond
Successful conversion of N-phenyl-N-tosylfluoroacetamides to amides and imides
Demonstrated efficient nucleophilic addition with tested reagents
Reactions proceeded without the need for transition metal catalysts

Implication

Demonstrates nucleophilic addition transforming N-phenyl-N-tosylfluoroacetamides into amides and imides, indicating a novel chemical pathway.

Abstract

The strained C−N bond of N-phenyl-N-tosylfluoroacetamides is activated via transition-metal-free nucleophilic addition pathway by employing suitable nucleophilic reagents, such as indoles, indolines, aryl amines and carboxylic acids. Based on this,...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/699e9177f5123be5ed04ef66 https://doi.org/10.1039/d6qo00069j

View Full Paper

Ask AI

Bookmark

Share

Divergent Transformations of N-Phenyl-N-tosylfluoroacetamides to Amides and Imides (N-Tosylamides)

Key Points

Implication

Abstract

Discussion

Cite This Study

Divergent Transformations of N-Phenyl-N-tosylfluoroacetamides to Amides and Imides (N-Tosylamides)

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading