Genome-wide association study reveals immune loci impacting steroid-sensitive nephrotic syndrome susceptibility, suggesting implications for genetic research.
We identified two novel immune-related loci associated with susceptibility to SSNS, nominating M6PR and ORMDL3 as potential contributors to SSNS risk in a cell-type-specific manner, and confirmed the association of PRS with earlier disease onset. These findings expand our knowledge of the genetic architecture of SSNS and highlight the importance of large-scale collaborations in uncovering genetic associations related to SSNS.
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Yang et al. (2026) studied this question.
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