What question did this study set out to answer?

This study aims to understand how spinal cord injury affects cognitive functions, specifically executive functions.

February 25, 2026Brain CommunicationsOpen Access

Altered functional connectivity underpins cognitive changes in chronic spinal cord injury

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Prospective observational study investigates cognitive impairment in spinal cord injury, indicating neural correlates of executive functions.

This study aims to understand how spinal cord injury affects cognitive functions, specifically executive functions.
Conducted a phonemic verbal fluency task during functional magnetic resonance imaging.
Compared task performance and brain activity between spinal cord injury and non-injured control groups.
Analyzed functional connectivity using general linear models and Pearson correlation.
Spinal cord injury individuals performed 15% worse on the verbal fluency task compared to controls (p=0.02).
Lower brain activity observed in the right putamen for spinal cord injury individuals (p=0.015).
Reduced functional connectivity between left insula and superior frontal gyrus in spinal cord injury individuals (p<0.001).
Negative correlation between verbal fluency performance and functional connectivity in specific brain regions.

Sritharan et al. (2026) studied this question.

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Prospective observational study investigates cognitive impairment in spinal cord injury, indicating neural correlates of executive functions.