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May 31, 2026Open Access

Altered functional connectivity underpins cognitive changes in chronic spinal cord injury.

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Authors

JSJothini SritharanBeth Israel Deaconess Medical CenterLDLorenzo DianaVVVanessa VallesiUniversity of Bern

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Implication

Prospective observational study investigates neural correlates of executive functions in spinal cord injury, indicating significant cognitive impairment.

Key Points

  • This study aims to explore brain activity and connectivity changes related to cognitive impairments in individuals with spinal cord injury.
  • Observed 26 individuals with spinal cord injury and 26 matched controls performing a phonemic verbal fluency task using fMRI.
  • Compared task performance and brain activity, analyzing functional connectivity using general linear models.
  • Correlated performance on verbal fluency with functional connectivity using Pearson correlation.
  • Spinal cord injury individuals showed 15% lower performance on the verbal fluency task compared to controls (P = 0.02).
  • Significantly reduced brain activity observed in the right putamen for spinal cord injury group compared to controls (P = 0.015).
  • Lower functional connectivity between the left insula and superior frontal gyrus in spinal cord injury individuals (P < 0.001).

Cite This Study

Sritharan et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd1745783ba022b6fd0b2https://doi.org/10.48620/98026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered functional connectivity underpins cognitive changes in chronic spinal cord injury2026 · 1 citations
  2. 2Spinal cord injury is associated with reduced cognitive capacity to self-regulate, organise and adapt to new situations2026
  3. 3Resting-state brain network alterations in spinal cord injury patients: an fNIRS study2026
  4. 4Brain activation during the N-back working memory task in individuals with spinal cord injury: a functional near-infrared spectroscopy study2024 · 6 citations
  5. 5Functional alterations across motor, visual, and attention cerebellar and cortical networks in patients with asymptomatic spinal cord compression2025 · 1 citations