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June 13, 2001JAMA

Validation of Clinical Classification Schemes for Predicting Stroke

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Why the study?

Do clinical classification schemes, specifically the CHADS2 index, accurately quantify the risk of stroke in patients with atrial fibrillation?

Population

Patients who have AF (atrial fibrillation)

Design

Cohort

Authors

Brian F. GageBrian F. GagePreventive CardiologyAWAmy D. WatermanHouston MethodistWSWilliam D. ShannonWashington University in St. Louis

Discussion

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Implication

CHADS2 may aid AF stroke risk stratification; extends prior schemes but leaves open need for prospective validation.

Structured PICO

Do clinical classification schemes, specifically the CHADS2 index, accurately quantify the risk of stroke in patients with atrial fibrillation?

P
Population
Patients who have AF (atrial fibrillation)
I
Intervention
Clinical classification schemes for predicting stroke (specifically the new CHADS2 index)
O
Outcome
Risk of strokehard clinical

The CHADS2 score is a valid tool for quantifying stroke risk in patients with atrial fibrillation, aiding in the selection of appropriate antithrombotic therapy.

Cite This Study

Gage et al. (2001) studied this question.

synapsesocial.com/papers/699f5f9f44800e1deffeb161https://doi.org/10.1001/jama.285.22.2864

Topics

Atrial fibrillationPersistent AF managementAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial fibrillation as a risk factor for stroke: a retrospective cohort study of hospitalized Medicare beneficiaries.1998 · 49 citations
  2. 2MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS1996 · 10,019 citations
  3. 3Warfarin in atrial fibrillation: underused in the elderly, often inappropriately used in the young1999 · 31 citations
  4. 4Statistical Methods for Survival Data Analysis.1993 · 2,853 citations
  5. 5Cost-Effectiveness of Preference-Based Antithrombotic Therapy for Patients With Nonvalvular Atrial Fibrillation1998 · 113 citations