Serum calprotectin elevation and interferon-α-induced neutrophil priming in macrophage activation syndrome associated with systemic lupus erythematosus: clinical and experimental insights

Key Points

• To explore the role of serum calprotectin as a biomarker in diagnosing macrophage activation syndrome associated with systemic lupus erythematosus.
• Clinical and experimental analysis of serum calprotectin levels
• Assessment of neutrophil activation in the presence of interferon-α
• Evaluation of patients diagnosed with systemic lupus erythematosus
• Serum calprotectin is significantly elevated in patients with macrophage activation syndrome
• Interferon-α is linked to the upregulation of calprotectin
• Calprotectin may aid in diagnosing macrophage activation syndrome in systemic lupus erythematosus patients