What question did this study set out to answer?

To investigate the molecular mechanisms by which disinfectants contribute to antibiotic resistance in biofilm-forming Escherichia coli.

February 26, 2026Open Access

Molecular Mechanisms of Disinfectant-Induced Cross-Resistance in Neonatal Care Units -Associated Escherichia Coli

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Study reveals disinfectants raise biofilm formation and multidrug resistance in Escherichia coli, indicating caution in neonatal care.

To investigate the molecular mechanisms by which disinfectants contribute to antibiotic resistance in biofilm-forming Escherichia coli.
Analyzed 35 Escherichia coli strains from neonatal care units
Exposed strains to quaternary ammonium compounds, chlorhexidine, ethanol, and sodium hypochlorite
Conducted biofilm assays, QPCR, and antibiotic susceptibility testing
QAC treatment increased biofilm formation by 20% and MDR prevalence from 52.9% to 64.7%
Chlorhexidine increased biofilm formation by 8.7% and β-lactam resistance by 5.9%
Ethanol and sodium hypochlorite decreased biofilm formation by 33.3% and 25.6%, respectively, and reduced MDR to 47.1%

Ibrahim Fouad Mohamed (2026) studied this question.

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