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February 26, 20261 citations

Characterizing pseudoangiomatous stromal hyperplasia (PASH) of the breast.

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RKRahul KoshyPJPragya JainJJJulie M. Jorns

Key Points

  • To characterize the features of pseudoangiomatous stromal hyperplasia in the breast and evaluate its relationship with hormone expression and cancer risk.
  • Analyzed ER/PR expression levels in PASH cases.
  • Documented occurrences of fat necrosis and fibrocystic changes.
  • Evaluated CD34 positivity and absence of markers in histologic mimics.
  • ER/PR expression in PASH is less frequent than reported in other studies.
  • Fat necrosis and fibrocystic changes support a chronic hormone-related process.
  • PASH does not appear to increase cancer risk.

Abstract

ER/PR expression in PASH is less frequent than previously reported by some studies. However, the frequency of fat necrosis and associated fibrocystic changes in PASH support a chronic, hormone-related process. Consistent CD34 positivity and absence of markers seen in histologic mimics aid in the diagnosis of PASH in challenging cases. PASH does not appear to impart increased cancer risk.

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Cite This Study

Koshy et al. (2026) studied this question.

synapsesocial.com/papers/699f95951bc9fecf3dab37b4https://doi.org/10.1111/his.70127
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