Triclosan-Isatin Hybrids as Potent Anti-proliferative Agents Inducing S-Phase Arrest via DNA Gyrase Inhibition in Triple-Negative Breast Cancer

Vipan Kumar; Shekhar Shekhar; Asif Raza; Sukhmanpreet Kaur; Amit Anand; Arun Kumar Sharma

doi:10.1039/d6md00013d

January 1, 2026RSC Medicinal Chemistry

Triclosan-Isatin Hybrids as Potent Anti-proliferative Agents Inducing S-Phase Arrest via DNA Gyrase Inhibition in Triple-Negative Breast Cancer

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Key Points

To evaluate the antiproliferative activity of Triclosan-Isatin hybrids against Triple-Negative Breast Cancer.
Synthesis of 1H-1,2,3-triazole-tethered TCS–isatin hybrid compounds.
Evaluation of antiproliferative effects on MDA-MB-231 and MDA-MB-468 cell lines.
The hybrids showed remarkable antiproliferative activity against the tested cell lines.
S-Phase arrest was induced via DNA gyrase inhibition.

Implication

Hybrid compounds demonstrate strong anticancer effects in triple-negative breast cancer cells, implying potential as therapeutic agents.

Abstract

A series of 1H-1,2,3-triazole-tethered TCS–isatin hybrid compounds were synthesized and evaluated for their antiproliferative activity against triple-negative breast cancer (TNBC). These hybrids exhibited remarkable potency against MDA-MB-231 and MDA-MB-468 cell...

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Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/699f95ba1bc9fecf3dab3d14 https://doi.org/10.1039/d6md00013d

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Triclosan-Isatin Hybrids as Potent Anti-proliferative Agents Inducing S-Phase Arrest via DNA Gyrase Inhibition in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Triclosan-Isatin Hybrids as Potent Anti-proliferative Agents Inducing S-Phase Arrest via DNA Gyrase Inhibition in Triple-Negative Breast Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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