What does this research mean for the field?

Extreme acidosis (pH ≤ 7) in hospitalized patients is associated with a 30-day mortality rate of 45.8%, with mixed and respiratory acidosis linked to higher mortality hazards compared to metabolic acidosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This study aims to analyze demographics, causes, and outcomes of hospitalised patients with extreme acidosis, focusing on 30-day mortality.

February 26, 2026Critical Care and ResuscitationOpen Access

Extreme acidosis in hospitalised patients: A 10-year single-centre, retrospective analysis

View Full Paper

Ask AI

Bookmark

Authors

ZGZoe Yuxiaoyan Guo HWHannah R WalkerThe University of Melbourne ABAlastair J. Brown

Discussion

Member takes

Implication

Retrospective cohort study examines outcomes of extreme acidosis in hospitalised patients, suggesting significant mortality risk related to its type and cause.

Key Points

This study aims to analyze demographics, causes, and outcomes of hospitalised patients with extreme acidosis, focusing on 30-day mortality.
Retrospective analysis of data from a single tertiary hospital over 10 years.
Patients with pH ≤ 7.0 identified from the hospital pathology database.
Excluded readmissions or non-inpatient samples.
Utilised a Cox proportional hazards model for data analysis.
Out of 493 patients, 45.8% died within 30 days of extreme acidosis.
Mixed acidosis and cardiorespiratory arrest were the most common types identified.
Patients with vascular causes had the highest risk of 30-day mortality (aHR: 31.2).
Mortality risk was significantly higher for mixed (aHR: 2.25) and respiratory acidosis (aHR: 2.08) compared to metabolic acidosis.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/699fe24b95ddcd3a253e61c1 https://doi.org/10.1016/j.ccrj.2025.100160

View Full Paper

Ask AI

Bookmark

Implication

Retrospective cohort study examines outcomes of extreme acidosis in hospitalised patients, suggesting significant mortality risk related to its type and cause.

Extreme acidosis in hospitalised patients: A 10-year single-centre, retrospective analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Extreme acidosis in hospitalised patients: A 10-year single-centre, retrospective analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider