What question did this study set out to answer?

The study aims to evaluate the effectiveness of handheld confocal laser endomicroscopy for diagnosing surgical biopsy specimens.

February 26, 2026Veterinary Pathology

Application of confocal laser microscopy and its feasibility in routine diagnosis of surgical biopsy specimens

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Authors

YJYea Ji Jeong GFGabrielle S. FontesThe Ohio State University LSLaura E. SelmicThe Ohio State University

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Implication

Demonstrates improved diagnostic accuracy using confocal laser endomicroscopy in surgical biopsy specimens, highlighting its potential for routine use.

Key Points

The study aims to evaluate the effectiveness of handheld confocal laser endomicroscopy for diagnosing surgical biopsy specimens.
Utilized handheld confocal laser endomicroscopy to capture images of surgical biopsy and autopsy specimens.
Involved 14 participants, including anatomic pathologists and residents, who assessed 17 cases.
Evaluated diagnostic performance with and without accompanying clinical history.
Statistical analysis was conducted using paired t-tests for accuracy measurement.
Participants distinguished abnormal tissue in 15 out of 17 cases.
Diagnosed neoplasia versus inflammation accurately in 12 out of 17 cases.
Correctly identified the cellular morphology of neoplasia in 8 out of 13 cases.
Significant improvement in diagnostic accuracy when clinical history was provided (P-value: 3.07E−07 to .005).

Cite This Study

Jeong et al. (2026) studied this question.

synapsesocial.com/papers/699fe40c95ddcd3a253e840f https://doi.org/10.1177/03009858261423164

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Implication

Demonstrates improved diagnostic accuracy using confocal laser endomicroscopy in surgical biopsy specimens, highlighting its potential for routine use.

Application of confocal laser microscopy and its feasibility in routine diagnosis of surgical biopsy specimens

Discussion

Member takes

Implication

Key Points

Cite This Study

Application of confocal laser microscopy and its feasibility in routine diagnosis of surgical biopsy specimens

Discussion

Member takes

Implication

Key Points

Cite This Study

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