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This research investigates the relationship between thyroid function tests and treatment outcomes in euthyroid patients with severe depression receiving electroconvulsive therapy.

February 26, 2026Journal of Clinical MedicineOpen Access

Revisiting Thyroid Function in Patients Undergoing Electroconvulsive Therapy for Severe or Treatment-Resistant Depression

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Authors

EMEmre MutluHacettepe University ABAdile Begüm BahçecioğluGülhane Askerî Tıp Akademisi ŞGŞeref Can GürelHacettepe University

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Cohort study examines thyroid function and depression response in euthyroid patients, indicating nuanced biological patterns.

Key Points

This research investigates the relationship between thyroid function tests and treatment outcomes in euthyroid patients with severe depression receiving electroconvulsive therapy.
Conducted a retrospective cohort study with 107 inpatients receiving ECT.
Analyzed 76 euthyroid patients using clinical data and HAMD scores.
Performed logistic and multiple linear regression analyses.
Utilized hierarchical clustering to identify subgroups based on clinical features.
No significant association found between TFTs and ECT response.
Baseline HAMD scores positively correlated with free-T4 levels.
Two subgroups identified: one with lower TSH levels despite similar ECT response rates.

Cite This Study

Mutlu et al. (2026) studied this question.

synapsesocial.com/papers/699fe41d95ddcd3a253e8693 https://doi.org/10.3390/jcm15051740

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Revisiting Thyroid Function in Patients Undergoing Electroconvulsive Therapy for Severe or Treatment-Resistant Depression

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Key Points

Cite This Study

Revisiting Thyroid Function in Patients Undergoing Electroconvulsive Therapy for Severe or Treatment-Resistant Depression

Discussion

Member takes

Implication

Key Points

Cite This Study

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