What question did this study set out to answer?

The study aims to evaluate the effectiveness of seizure threshold-titrated ECT in patients with treatment-resistant depression and explore how seizure characteristics and treatment variables impact clinical outcomes.

July 30, 2026Journal of Clinical MedicineOpen Access

Clinical Outcomes and Treatment Characteristics of Seizure Threshold-Titrated Electroconvulsive Therapy in Depressive Disorder: A 3.5-Year Retrospective Naturalistic Course-Level Study

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The study aims to evaluate the effectiveness of seizure threshold-titrated ECT in patients with treatment-resistant depression and explore how seizure characteristics and treatment variables impact clinical outcomes.
Retrospective naturalistic study conducted at Dr. Gh. Preda Clinical Psychiatric Hospital, Romania
Included consecutive patients treated with ECT for treatment-resistant depression from March 2022 to December 2025
Assessed clinical outcomes using MADRS, BDI, MMSE, and GAF scores, collecting relevant treatment data.
Median MADRS scores improved from 38 to 20 (p < 0.001) after ECT, showing significant symptom reduction.
57.9% of ECT courses resulted in clinical response, with 36.8% achieving remission.
Self-reported depressive symptoms decreased, with median BDI scores dropping from 38 to 16 and median GAF scores rising from 55 to 65.

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Implication

Retrospective study evaluates seizure threshold-titrated ECT effectiveness in treatment-resistant depression, indicating positive outcomes.

Cite This Study

Anghel et al. (2026) studied this question.

synapsesocial.com/papers/6a6af4e960e2b924d3ea06c2 https://doi.org/10.3390/jcm15155890

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Implication

Retrospective study evaluates seizure threshold-titrated ECT effectiveness in treatment-resistant depression, indicating positive outcomes.

Clinical Outcomes and Treatment Characteristics of Seizure Threshold-Titrated Electroconvulsive Therapy in Depressive Disorder: A 3.5-Year Retrospective Naturalistic Course-Level Study

Key Points

Discussion

Implication

Cite This Study

Clinical Outcomes and Treatment Characteristics of Seizure Threshold-Titrated Electroconvulsive Therapy in Depressive Disorder: A 3.5-Year Retrospective Naturalistic Course-Level Study

Key Points

Discussion

Implication

Cite This Study

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