Key result
Higher ECT seizure quality was significantly associated with a decrease in depressive symptomatology (P = 9.9 × 10), while 61.5% of patients with poor-quality seizures relapsed at 1 month.
Why the study?
Do ECT seizure quality markers predict treatment response in patients with treatment-resistant depression?
Population
45 patients with treatment-resistant depression receiving electroconvulsive therapy (ECT)
Design
Cohort, double-blind manner
Follow-up
approximately 1 month from the last ECT session
Authors
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ECT seizure quality markers may predict response in resistant depression; hypothesis-generating pending randomized trials.
Observational (n=45)
Double-blind
Do ECT seizure quality markers predict treatment response in patients with treatment-resistant depression?
p-value: p=9.9 × 10
ECT seizure quality markers, particularly hemispheric brain wave synchronicity and wave amplitude, are strongly correlated with the decrease of depressive symptomatology in treatment-resistant depression.
Minelli et al. (2015) conducted an observational in Treatment-resistant depression (n=45). ECT seizure quality vs. Poor-quality seizures was evaluated on Decrease of depressive symptomatology (p=9.9 × 10). Higher ECT seizure quality was significantly associated with a decrease in depressive symptomatology (P = 9.9 × 10), while 61.5% of patients with poor-quality seizures relapsed at 1 month.
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