January 1, 1984CirculationOpen Access

A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient.

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Why the study?

Do intravenous and oral amiodarone have the same electrophysiologic effects in patients with Wolff-Parkinson-White syndrome or ventricular tachycardia?

Population

12 patients (nine with Wolff-Parkinson-White syndrome and three with ventricular tachycardia)

Comparison

Intravenous amiodarone vs Oral amiodarone in the same patient

Design

Case_series

Authors

HWH. J. J. WellensMaastricht University PBPedro BrugadaElectrophysiology HAHoshiar AbdollahQueen's University

Discussion

Member takes

Implication

IV and oral amiodarone warrant distinct EP consideration; case report leaves open route-specific trials in WPW/VT.

Structured PICO

Do intravenous and oral amiodarone have the same electrophysiologic effects in patients with Wolff-Parkinson-White syndrome or ventricular tachycardia?

Population

12 patients (nine with Wolff-Parkinson-White syndrome and three with ventricular tachycardia)

Intervention

Intravenous amiodarone (5 mg/kg body weight in 1 min)

Comparator

Oral amiodarone (total dose 9800 to 11,200 mg) in the same patient

Outcome

Electrophysiologic effects measured by programmed stimulation of the heart (including effective refractory periods, AH interval, HV interval, and tachycardia rate)surrogate

Intravenous and oral amiodarone exhibit distinct electrophysiologic profiles in the same patients, suggesting differences in mechanism possibly due to cumulative effects or active metabolites.

Cite This Study

Wellens et al. (1984) studied this question.

synapsesocial.com/papers/699fea8452ece5d8a8069218 https://doi.org/10.1161/01.cir.69.1.120

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January 1, 1984CirculationOpen Access

A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient.

View Full Paper

Ask AI

Bookmark

Why the study?

Do intravenous and oral amiodarone have the same electrophysiologic effects in patients with Wolff-Parkinson-White syndrome or ventricular tachycardia?

Population

12 patients (nine with Wolff-Parkinson-White syndrome and three with ventricular tachycardia)

Comparison

Intravenous amiodarone vs Oral amiodarone in the same patient

Design

Case_series

Authors

HWH. J. J. WellensMaastricht University PBPedro BrugadaElectrophysiology HAHoshiar AbdollahQueen's University

Discussion

Member takes

Implication

IV and oral amiodarone warrant distinct EP consideration; case report leaves open route-specific trials in WPW/VT.

Structured PICO

Do intravenous and oral amiodarone have the same electrophysiologic effects in patients with Wolff-Parkinson-White syndrome or ventricular tachycardia?

Population

12 patients (nine with Wolff-Parkinson-White syndrome and three with ventricular tachycardia)

Intervention

Intravenous amiodarone (5 mg/kg body weight in 1 min)

Comparator

Oral amiodarone (total dose 9800 to 11,200 mg) in the same patient

Outcome

Electrophysiologic effects measured by programmed stimulation of the heart (including effective refractory periods, AH interval, HV interval, and tachycardia rate)surrogate

Intravenous and oral amiodarone exhibit distinct electrophysiologic profiles in the same patients, suggesting differences in mechanism possibly due to cumulative effects or active metabolites.

Cite This Study

Wellens et al. (1984) studied this question.

synapsesocial.com/papers/699fea8452ece5d8a8069218 https://doi.org/10.1161/01.cir.69.1.120

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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