What question did this study set out to answer?

To describe the expansion, data access improvements, and functional annotation initiatives across viral, prokaryotic, and eukaryotic branches in NCBI's Reference Sequence (RefSeq) database.

November 8, 2015Nucleic Acids ResearchOpen Access

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

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Authors

NONuala A. O’LearyNational Institutes of Health MWMatt W. WrightLeiden University JBJ. Rodney BristerNational Institutes of Health

Discussion

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Implication

Database report demonstrates expansion to over 55,000 organisms with enhanced functional annotation, highlighting improved resources for comparative genomics and clinical testing.

Key Points

To describe the expansion, data access improvements, and functional annotation initiatives across viral, prokaryotic, and eukaryotic branches in NCBI's Reference Sequence (RefSeq) database.
Curated non-redundant reference genomes, transcripts, and proteins by combining primary sequence submissions from INSDC with computational pipelines and expert manual curation.
Integrated high-throughput experimental evidence, including RNA-Seq data, to refine gene models and functional features in vertebrates, plants, and other taxa.
Established updated management workflows for prokaryotic genome sequences and standardized protein nomenclature.
RefSeq release 71 expanded to encompass sequences from over 55,000 organisms, spanning more than 4,800 viruses, 40,000 prokaryotes, and 10,000 eukaryotes.
Implemented comprehensive functional curation frameworks to provide standardized data for comparative genomics, taxonomic validation, and clinical sequence interpretation.

Cite This Study

O’Leary et al. (2015) studied this question.

synapsesocial.com/papers/69a011ae52ece5d8a806924d https://doi.org/10.1093/nar/gkv1189

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November 8, 2015Nucleic Acids ResearchOpen Access

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

View Full Paper

Ask AI

Bookmark

Authors

NONuala A. O’LearyNational Institutes of Health MWMatt W. WrightLeiden University JBJ. Rodney BristerNational Institutes of Health

Discussion

Member takes

Implication

Database report demonstrates expansion to over 55,000 organisms with enhanced functional annotation, highlighting improved resources for comparative genomics and clinical testing.

Key Points

To describe the expansion, data access improvements, and functional annotation initiatives across viral, prokaryotic, and eukaryotic branches in NCBI's Reference Sequence (RefSeq) database.
Curated non-redundant reference genomes, transcripts, and proteins by combining primary sequence submissions from INSDC with computational pipelines and expert manual curation.
Integrated high-throughput experimental evidence, including RNA-Seq data, to refine gene models and functional features in vertebrates, plants, and other taxa.
Established updated management workflows for prokaryotic genome sequences and standardized protein nomenclature.
RefSeq release 71 expanded to encompass sequences from over 55,000 organisms, spanning more than 4,800 viruses, 40,000 prokaryotes, and 10,000 eukaryotes.
Implemented comprehensive functional curation frameworks to provide standardized data for comparative genomics, taxonomic validation, and clinical sequence interpretation.

Cite This Study

O’Leary et al. (2015) studied this question.

synapsesocial.com/papers/69a011ae52ece5d8a806924d https://doi.org/10.1093/nar/gkv1189

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