What question did this study set out to answer?

This review aims to synthesize current evidence on the systemic effects of metabolic acidosis and its mechanisms contributing to organ dysfunction.

Systemic effects of metabolic acidosis

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Literature review explores systemic physiological effects of metabolic acidosis, suggesting implications for organ dysfunction.

This review aims to synthesize current evidence on the systemic effects of metabolic acidosis and its mechanisms contributing to organ dysfunction.
Conducted a comprehensive literature review on metabolic acidosis effects
Analyzed cardiovascular, vascular, pulmonary, gastrointestinal, endocrine, musculoskeletal, renal, and metabolic systems
Searched for physiological mechanisms influencing system interactions
Impaired cardiac performance and altered ion currents in the cardiovascular system
Vasodilation in large arteries and vasoconstriction in small vessels depending on metabolic acidosis
Increased pulmonary vascular resistance and hyperventilation observed
Gastrointestinal adaptations include changes in mucus production and blood flow
Endocrine shifts affect growth hormone and thyroid hormone activities

Chen et al. (2026) studied this question.

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