PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 27, 2026JAMA Psychiatry5 citations

Brain and Blood Biomarkers of Major Depressive Disorder

View Full Paper
LZLia J. ZallarMDMaura B. Dupont

Key Points

  • This research aims to identify biomarkers and treatment targets for major depressive disorder (MDD) through the analysis of dysregulated genes and pathways.
  • Review of studies on gene dysregulation in MDD across various brain regions
  • Analysis of converging pathways and hub gene functions
  • Call for multiomic studies focusing on understudied brain regions
  • Dysregulated genes vary across studies and brain regions
  • Common pathways related to neurodevelopment, mitochondria, and neuroinflammation are identified
  • Need for specific studies in understudied brain regions to better understand MDD

Abstract

While the individual dysregulated genes are highly variable across studies and brain regions, converging pathways and hub gene functions, including those related to neurodevelopment, mitochondria, neuroinflammation, apoptosis, and transcriptional regulation emerge across studies. Cell-type specific multiomic studies involving understudied brain regions are needed to better understand the pathophysiology of MDD and identify relevant biomarkers and treatment targets.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Zallar et al. (2026) studied this question.

synapsesocial.com/papers/69a1350eed1d949a99abe85chttps://doi.org/10.1001/jamapsychiatry.2025.4613
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peripheral molecular signatures of major depressive disorder: a systematic review of blood-derived biomarkers for diagnosis, stratification, and treatment response2026
  2. 2From brain networks to peripheral signatures: candidate biomarkers for major depressive disorder2026
  3. 3Analysis of Genomic and Transcriptomic Data Revealed Key Genes and Processes in the Development of Major Depressive Disorder2025
  4. 4Integrative transcriptomic meta-analysis reveals immune, synaptic, and non-coding RNA dysregulation in bipolar disorder across brain and blood2026
  5. 5Cytokine-Related Genes and Inflammatory Profiles as Potential Biomarkers in Major Depressive Disorder2025 · 6 citations