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This study aims to investigate how lymph node yield influences survival outcomes in patients with esophageal and gastric cancer post-surgery.

Lymph node yield and its impact on survival outcomes: a retrospective multicenter cohort study from Denmark

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This study aims to investigate how lymph node yield influences survival outcomes in patients with esophageal and gastric cancer post-surgery.
Retrospective multicenter cohort study conducted in Denmark.
Included 3092 patients undergoing curative resection for esophageal and gastric cancers from 2013 to 2021.
Patients stratified by nodal status and categorized into five lymph node yield groups.
Survival analysis performed using Kaplan–Meier curves and multivariable Cox regression.
Higher lymph node yields were significantly linked to improved survival in node-negative esophageal cancer patients.
No survival benefit was observed for node-positive esophageal or gastric cancer patients when more than 16–19 nodes were removed.
Perioperative chemotherapy improved survival for node-positive esophageal cancer, but not for node-negative counterparts.
Discrepancies in clinical and pathological staging often affected survival estimates and treatment decisions.

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Multicenter cohort study evaluates lymph node yield's impact on survival outcomes in cancer patients, suggesting treatment implications.

Kempf et al. (2026) studied this question.

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