What question did this study set out to answer?

To identify a lymph node yield change-point related to overall and disease-free survival in esophageal adenocarcinoma patients post-neoadjuvant treatment.

August 2, 2026Annals of Surgery

The Prognostic Impact of Lymph Node Yield Upon Survival in Esophageal Cancer Broken Down by Neoadjuvant Strategy

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To identify a lymph node yield change-point related to overall and disease-free survival in esophageal adenocarcinoma patients post-neoadjuvant treatment.
Multicenter European study from 2018 to 2023 with 2069 patients undergoing esophagectomy after chemotherapy or chemoradiotherapy.
RA-CUSUM analysis to find change points; bootstrap resampling for optimal lymph node yield; multivariable Cox models for analysis.
Post hoc exploratory subgroup analysis compared optimal lymph node yields in chemotherapy versus chemoradiotherapy groups.
Optimal lymph node yield threshold of 25 nodes identified for chemotherapy patients (HR: 0.714, P=0.0017).
Chemotherapy patients with ≥25 lymph nodes had a ∼44% lower mortality compared to chemoradiotherapy (HR=0.563, P<0.001).
Disease recurrence was 32.7% in chemotherapy versus 38.3% in chemoradiotherapy (P=0.001).

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Implication

Randomized trial assesses survival benefits of lymph node yield in esophageal cancer patients post neoadjuvant treatment, indicating important clinical implications.

Cite This Study

Guidozzi et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeb201b0468a7eeab3fee https://doi.org/10.1097/sla.0000000000007164

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Implication

Randomized trial assesses survival benefits of lymph node yield in esophageal cancer patients post neoadjuvant treatment, indicating important clinical implications.

The Prognostic Impact of Lymph Node Yield Upon Survival in Esophageal Cancer Broken Down by Neoadjuvant Strategy

Key Points

Discussion

Implication

Cite This Study

The Prognostic Impact of Lymph Node Yield Upon Survival in Esophageal Cancer Broken Down by Neoadjuvant Strategy

Key Points

Discussion

Implication

Cite This Study

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