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This research aims to explore the role of NQO1 in glioblastoma treatment and its impact on oxidative stress and tumor microenvironment.

February 27, 2026Neuro-Oncology

NQO1-Mediated Oxidative Stress Resistance and Tumor Microenvironment Remodeling in Glioblastoma

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This research aims to explore the role of NQO1 in glioblastoma treatment and its impact on oxidative stress and tumor microenvironment.
Targeting NQO1 and its signaling pathways
Utilizing β-Lapachone
Employing anti-PD-1 therapy as an immune checkpoint inhibitor
Analyzing interactions between GSCs and the tumor microenvironment
Targeting NQO1 enhances oxidative stress resistance
β-Lapachone shows potential in remodeling tumor microenvironment
Immune checkpoint inhibitors improve therapeutic outcomes in GBM

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Observational analysis reveals NQO1's influence on tumor microenvironment in glioblastoma, suggesting new treatment strategies.

Li et al. (2026) studied this question.

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