Autosomal Dominant Hyper-IgE Syndrome Patients Retain IL10-Producing preTh17-Cells That Are Activated by Opportunistic Pathogens and Support IgE Production.

Q: What does this research mean for the field?

AD-HIES patients retain IL-10-producing pre-Th17-cells that are activated by opportunistic pathogens and support aberrant IgE production. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

Giorgia Moschetti; Chiara Vasco; Francesca Clemente; Paola Larghi; Sara Maioli; Edoardo Scarpa; Elena Carelli; Nadia Pulvirenti; Maria Lucia Sarnicola; Mariacristina Crosti; Manal Bel Imam; Willem van de Veen; Loris Rizzello; Sergio Abrignani; Lucia Augusta Baselli; Dellepiane Rm; Maria Carrabba; Giovanna Fabio; Jens Geginat

doi:10.1111/all.70266

Key Points

This research aims to investigate the status and function of IL-10-producing pre-Th17-cells in patients with Autosomal Dominant Hyper-IgE Syndrome (AD-HIES).
Analyzed Th17 differentiation in AD-HIES patients
Evaluated IL-10 production in CD4+ T-cells
Assessed activation of pre-Th17-cells by AD-HIES-associated pathogens
Examined B-helper functions of pre-Th17-cells
Pre-Th17 differentiation is arrested at an intermediate stage in AD-HIES patients
IL-10 production by CD4+ T-cells remains unaffected by DN-STAT3 mutations
Pre-Th17-cells promote aberrant IgE production instead of providing protection

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Implication

Findings reveal that pre-Th17-cells in AD-HIES support IgE production, suggesting a role in opportunistic infections.

Abstract

Th17 differentiation in AD-HIES patients was not completely impaired but arrested at an intermediate stage of IL-10-producing "pre-Th17"-cells. Surprisingly, DN-STAT3 mutations did not inhibit IL-10 production by CD4⁺T-cells. Pre-Th17-cells were activated by AD-HIES-associated pathogens and possessed B-helper functions, suggesting that they are not protective but may promote aberrant IgE production.

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Cite This Study

Moschetti et al. (2026) studied this question.

synapsesocial.com/papers/69a1359eed1d949a99abfa57 https://doi.org/10.1111/all.70266

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Autosomal Dominant Hyper-IgE Syndrome Patients Retain IL10-Producing preTh17-Cells That Are Activated by Opportunistic Pathogens and Support IgE Production.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Autosomal Dominant Hyper-IgE Syndrome Patients Retain IL10-Producing preTh17-Cells That Are Activated by Opportunistic Pathogens and Support IgE Production.

Key Points

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Implication

Abstract

Discussion

Cite This Study

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