What question did this study set out to answer?

To evaluate the effectiveness of minimally invasive surgery (MIS-TLIF) compared to open surgery (O-TLIF) in patients with lumbar stenosis and spondylolisthesis.

February 27, 2026Spine

MIS-TLIF vs Open TLIF in Combined Lumbar Stenosis and Low-grade Spondylolisthesis

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Authors

AKAleksandr KrutkoCentral Scientific Research Institute of Traumatology and Orthopedics NKNikita S. KuzminCenter for Science in the Public Interest (United States)EBEvgeniy A. BaykovCenter for Science in the Public Interest (United States)

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Implication

A randomized trial shows non-inferior clinical outcomes for MIS-TLIF in lumbar stenosis and spondylolisthesis, suggesting its efficacy.

Key Points

To evaluate the effectiveness of minimally invasive surgery (MIS-TLIF) compared to open surgery (O-TLIF) in patients with lumbar stenosis and spondylolisthesis.
Conducted a randomized, open-label, non-inferiority trial
Patients with symptomatic lumbar stenosis and low-grade spondylolisthesis were randomly assigned to MIS-TLIF or O-TLIF
Primary endpoint measured was change in Oswestry Disability Index (ODI) score at 3 months post-surgery
Mean difference in ODI score was 0.4 with a 90% confidence interval below the non-inferiority margin
82.8% of patients achieved the minimal clinically important difference (MCID) for the ODI
Open TLIF group had longer hospital stays and required more analgesia
MIS-TLIF had 10.5% higher direct costs compared to O-TLIF

Cite This Study

Krutko et al. (2026) studied this question.

synapsesocial.com/papers/69a135b0ed1d949a99abfc78 https://doi.org/10.1097/brs.0000000000005669

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MIS-TLIF vs Open TLIF in Combined Lumbar Stenosis and Low-grade Spondylolisthesis

Discussion

Member takes

Implication

Key Points

Cite This Study

MIS-TLIF vs Open TLIF in Combined Lumbar Stenosis and Low-grade Spondylolisthesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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