What question did this study set out to answer?

To compare minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) with open surgery (OS) for low-grade lumbar spondylolisthesis in terms of fusion and complications.

July 22, 2026Spine DeformityOpen Access

Minimally invasive versus open transforaminal lumbar interbody fusion for low grade lumbar spondylolisthesis: a systematic review and meta-analysis

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Authors

SPShaan PatelThomas Jefferson University Hospital SNShiva A. NischalUniversity of Cambridge GWGriffin W. WhiteDrexel University

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Implication

Systematic review compares fusion outcomes in minimally invasive and open surgery for lumbar spondylolisthesis, suggesting reduced complications.

Key Points

To compare minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) with open surgery (OS) for low-grade lumbar spondylolisthesis in terms of fusion and complications.
Systematic review and meta-analysis of studies comparing MIS-TLIF and OS-TLIF.
Searched databases include PubMed, Embase, and CENTRAL up to December 2025.
Nineteen studies with 2117 patients were analyzed using random-effects models.
Fusion outcomes were equivalent between MIS and OS with RR 1.13, 95% CI 0.74–1.74; P=0.51.
MIS showed reduced overall complications (RR 0.75; 95% CI 0.59–0.95; P=0.02) and surgical site infections (SSI) (RR 0.30; 95% CI 0.14–0.65; P=0.007).
MIS also resulted in lower blood loss (MD −194.0 mL; P < 0.001) and shorter length of stay (MD −2.1 days; P < 0.001).

Cite This Study

Patel et al. (2026) studied this question.

synapsesocial.com/papers/6a605ee84163e025518d86fb https://doi.org/10.1007/s43390-026-01508-6

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Implication

Systematic review compares fusion outcomes in minimally invasive and open surgery for lumbar spondylolisthesis, suggesting reduced complications.

Minimally invasive versus open transforaminal lumbar interbody fusion for low grade lumbar spondylolisthesis: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Minimally invasive versus open transforaminal lumbar interbody fusion for low grade lumbar spondylolisthesis: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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