Why the study?
Does the presence of structural heart disease or sinus node dysfunction affect the atrial effective refractory period in patients with atrial fibrillation compared to lone AF?
Does the presence of structural heart disease or sinus node dysfunction affect the atrial effective refractory period in patients with atrial fibrillation compared to lone AF?
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Atrial effective refractory periods are prolonged in AF patients with structural heart disease or sinus node dysfunction compared to lone AF, contrasting with the ERP shortening typically seen in persistent versus paroxysmal AF.
The mean atrial ERP was shorter in patients with PeAF than those with PAF due to electrical remodeling. In contrast, AF patients with SHD/SND showed a more prolonged mean atrial ERP than those with lone AF, associated with LA enlargement or left ventricular diastolic dysfunction.
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Uhm et al. (2012) studied this question.
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