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This research investigates the relationship between low-level lead exposure and the risk of hypertension, focusing on oxidative stress as a potential mediator.

February 28, 2026Ecotoxicology and Environmental SafetyOpen Access

Low-level lead exposure, risk of hypertension, and the mediating effect of oxidative stress: Evidence from Southern China

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This research investigates the relationship between low-level lead exposure and the risk of hypertension, focusing on oxidative stress as a potential mediator.
Utilized data from cross-sectional and follow-up studies involving lead-exposed workers in Southern China.
Conducted comprehensive assessments including demographics, physical exams, and lead exposure levels.
Applied logistic regression, mixed-effect models, and mediation analysis to explore associations and nonlinearity.
Included a subgroup analysis on oxidative damage indicators and behavioral factors.
Workers in the highest quartile of lead exposure showed a 38-65% increased risk of hypertension compared to the lowest quartile.
A nonlinear association was identified in the cross-sectional study, while a linear trend appeared in the follow-up study.
Older age and prolonged exposure duration were associated with increased blood pressure effects.
8-iso-PGF 2α mediated 56.6% of the association between lead exposure and blood pressure.

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Implication

Cross-sectional and follow-up studies reveal low-level lead exposure increases hypertension risk, highlighting oxidative stress as a mediator.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/69a285da0a974eb0d3c00bc7 https://doi.org/10.1016/j.ecoenv.2026.119949

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Implication

Cross-sectional and follow-up studies reveal low-level lead exposure increases hypertension risk, highlighting oxidative stress as a mediator.

Low-level lead exposure, risk of hypertension, and the mediating effect of oxidative stress: Evidence from Southern China

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Implication

Cite This Study

Low-level lead exposure, risk of hypertension, and the mediating effect of oxidative stress: Evidence from Southern China

Key Points

Discussion

Implication

Cite This Study

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