Treatment Outcomes and Factors Affecting Survival in Pediatric Acute Myeloid Leukemia

Puntos clave

• The study aims to evaluate survival outcomes and the influencing factors in pediatric acute myeloid leukemia patients.
• Retrospective evaluation of pediatric AML patients under 18 years from eastern Turkey between 2010 and 2023.
• Application of the AML-BFM 2004 and AML-BFM 2012 treatment protocols.
• Determination of risk groups based on chemotherapy response and genetic results.
• Survival analyses using the Kaplan-Meier method and Cox regression analyses.
• 81.6% of patients achieved complete remission after induction therapy.
• Overall mortality in patients was 38.8%, with higher rates in younger patients and those over 14 years.
• Five-year survival rates were significantly higher for AML-M3 patients at 94% compared to 43% for non-AML-M3 patients.
• Lower survival was associated with high leukocyte counts, low hemoglobin levels, and poor induction response.

Resumen