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Synapse
February 28, 2026Lab on a Chip0 citationsOpen Access

Integrated Strategy for Breast Cancer Biomarker Analysis Using Dual Ionic Liquid Aqueous Biphasic Systems and Microfluidic Immunoassays

MMMaria S. M. MendesIAInês AgostinhoMSMaria C. Souza

Key Points

  • The study aims to improve breast cancer biomarker analysis by utilizing dual ionic liquid aqueous biphasic systems and microfluidic immunoassays.
  • Developed a dual ionic liquid aqueous biphasic system for biomarker extraction.
  • Implemented microfluidic immunoassays for analyzing HER2 levels.
  • Conducted serum-based testing as an alternative to tissue biopsy.
  • Successfully detected HER2 levels in serum samples using the new method.
  • Showed that the dual ionic liquid system enhances biomarker recovery and specificity.
  • Indicated potential for faster and more accurate breast cancer diagnosis.

Abstract

Human epidermal growth factor receptor 2 (HER2) is a key biomarker in breast cancer diagnosis, prognosis, and therapeutic decision-making. While its determination is traditionally based on tissue biopsy, serum-based testing...

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Cite This Study

Mendes et al. (2026) studied this question.

synapsesocial.com/papers/69a286da0a974eb0d3c02292https://doi.org/10.1039/d5lc01010a
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Also Consider

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  1. 1HER2 status in breast cancer: changes in guidelines and complicating factors for interpretation2019 · 275 citations
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